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26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody (Biotin)
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Catalogue No: abx317158
Price:
US$188.50
(Size: 20 µg)
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26S Proteasome Regulatory Subunit 8 (PSMC5) Antibody (Biotin) is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 8 (PSMC5)V conjugated to Biotin. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene.
Research Articles on 26S Proteasome Regulatory Subunit 8 (PSMC5)
| Target | 26S Proteasome Regulatory Subunit 8 (PSMC5) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA |
| Host | Rabbit |
| Recommended dilutions | Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Biotin |
| Immunogen | Recombinant Human 26S protease regulatory subunit 8 protein (253-324AA). |
| Isotype | IgG |
| Form | Liquid |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P62195 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K3Z3, A8K763, O35051, O43208, P47210, P52915, P52916 |
| UniProt Entry Name | PRS8_HUMAN |
| Gene Symbol | PSMC5 |
| GeneID | 5705 |
| OMIM | 601681 |
| NCBI Accession | NP_001186092.1 NM_001199163.1 NP_002796.4 NM_002805.5 |
| KEGG | hsa:5705 |
| String | 9606.ENSP00000310572 |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |