26S Proteasome Regulatory Subunit 10B (PSMC6) Antibody is a Rabbit Polyclonal antibody against 26S Proteasome Regulatory Subunit 10B (PSMC6). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Target |
26S Proteasome Regulatory Subunit 10B (PSMC6) |
Clonality |
Polyclonal |
Reactivity |
Human, Mouse, Rat |
Tested Applications |
ELISA, WB |
Host |
Rabbit |
Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
Conjugation |
Unconjugated |
Immunogen |
Human PSMC6. |
Isotype |
IgG |
Form |
Liquid |
Purification |
Antigen Affinity Chromatography. |
Storage |
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
UniProt Primary AC |
P62333 (UniProt,
ExPASy)
|
UniProt Secondary AC |
B2R975, P49719, Q6IBU3, Q92530 |
UniProt Entry Name |
PRS10_HUMAN |
Gene Symbol |
PSMC6 |
GeneID |
5706
|
OMIM |
602708
|
HGNC |
9553
|
KEGG |
hsa:5706
|
Ensembl |
ENSG00000100519 |
String |
9606.ENSP00000401802
|
Buffer |
PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
Availability |
Shipped within 5-10 working days. |
Note |
This product is for research use only. |
Research Articles on 26S Proteasome Regulatory Subunit 10B (PSMC6)