26S Proteasome Regulatory Subunit 10B (PSMC6) Antibody

Rabbit Polyclonal against the 26S Proteasome Regulatory Subunit 10B (PSMC6) protein. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.

Target	26S Proteasome Regulatory Subunit 10B (PSMC6)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fragment corresponding to 135-296 AA of human PSMC6.
Isotype	IgG
Form	Lyophilized
Purification	Purified by antigen affinity column chromatography.
Reconstitution	Reconstitute in 100 µl of sterile distilled H2O with 50% glycerol.
Storage	Store at -20 °C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P62333 (UniProt, ExPASy)
UniProt Secondary AC	B2R975, P49719, Q6IBU3, Q92531
UniProt Entry Name	PRS10_HUMAN
Gene Symbol	PSMC6
GeneID	5706
OMIM	602708
NCBI Accession	BC005390
HGNC	9553
KEGG	hsa:5706
Ensembl	ENSG00000100519
String	9606.ENSP00000401802
Molecular Weight	Observed MW: 44 kDa
Buffer	Prior to lyophilization: 1% BSA and 0.02% NaN3.
Specificity	Predicted to react with Mouse and Rat PSMC6.
Concentration	Lyophilized form: Not applicable. After reconstitution: 1 mg/ml.
Availability	Shipped within 7-15 working days.
Note	This product is for research use only.

Research Articles on 26S Proteasome Regulatory Subunit 10B (PSMC6)

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