+44 (0) 1223 755950
+1 832 327 7413
26S Proteasome Regulatory Subunit 10B (PSMC6) Antibody
REQUEST MORE INFO
Catalogue No: abx236881
Price:
US$406.00
(Size: 100 µg)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
26S Proteasome Regulatory Subunit 10B (PSMC6) Antibody is a Rabbit Polyclonal against 26S Proteasome Regulatory Subunit 10B (PSMC6). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Research Articles on 26S Proteasome Regulatory Subunit 10B (PSMC6)
| Target | 26S Proteasome Regulatory Subunit 10B (PSMC6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | proteasome (prosome, macropain) 26S subunit, ATPase, 6 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P62333 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R975, P49719, Q6IBU3, Q92532 |
| UniProt Entry Name | PRS10_HUMAN |
| Gene Symbol | PSMC6 |
| GeneID | 5706 |
| OMIM | 602708 |
| HGNC | 9553 |
| KEGG | hsa:5706 |
| Ensembl | ENSG00000100519 |
| String | 9606.ENSP00000401802 |
| Molecular Weight | Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |