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26S Proteasome Regulatory Subunit 10B (PSMC6) Antibody
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Catalogue No: abx004118
Price:
US$217.50
(Size: 20 µl)
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26S Proteasome Regulatory Subunit 10B (PSMC6) Antibody is a Rabbit Polyclonal antibody against 26S Proteasome Regulatory Subunit 10B (PSMC6). The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12.
Research Articles on 26S Proteasome Regulatory Subunit 10B (PSMC6)
| Target | 26S Proteasome Regulatory Subunit 10B (PSMC6) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | ELISA: 1 µg/ml, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20-150 of human PSMC6. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P62333 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R975, P49719, Q6IBU3, Q92524 |
| UniProt Entry Name | PRS10_HUMAN |
| Gene Symbol | PSMC6 |
| GeneID | 5706 |
| OMIM | 602708 |
| NCBI Accession | NP_002797.3 |
| HGNC | 9553 |
| KEGG | hsa:5706 |
| Ensembl | ENSG00000100519 |
| String | 9606.ENSP00000401802 |
| Molecular Weight | Calculated MW: 44 kDa Observed MW: 45 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |