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26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) Antibody
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Catalogue No: abx236889
Price:
US$406.00
(Size: 100 µg)
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PSMD4 Antibody is a Rabbit Polyclonal against PSMD4. The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Research Articles on 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4)
| Target | 26S Proteasome Non-ATPase Regulatory Subunit 4 (PSMD4) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200, IF/ICC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | proteasome(prosome, macropain) 26S subunit, non-ATPase, 4 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | P55036 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DV16, Q5VWC5, Q9NS92 |
| UniProt Entry Name | PSMD4_HUMAN |
| Gene Symbol | PSMD4 |
| GeneID | 5710 |
| OMIM | 601648 |
| NCBI Accession | NP_002801.1 NM_002810.2 |
| HGNC | 9561 |
| KEGG | hsa:5710 |
| Ensembl | ENSG00000159352 |
| String | 9606.ENSP00000357879 |
| Molecular Weight | Observed MW: 50-55 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |