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Polypyrimidine Tract-Binding Protein 1 (PTBP1) Antibody
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Catalogue No: abx001513
Price:
US$232.00
(Size: 20 µl)
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PTBP1 Antibody is a Rabbit Polyclonal antibody against PTBP1. This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been describ.
Research Articles on Polypyrimidine Tract-Binding Protein 1 (PTBP1)
| Target | Polypyrimidine Tract-Binding Protein 1 (PTBP1) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human PTBP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P26599 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9BUQ0 |
| UniProt Entry Name | PTBP1_HUMAN |
| Gene Symbol | PTBP1 |
| GeneID | 5725 |
| NCBI Accession | NP_114368.1 |
| KEGG | hsa:5725 |
| String | 9606.ENSP00000349428 |
| Molecular Weight | Calculated MW: 60 kDa Observed MW: 57 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |