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PTEN (pY176) Antibody
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Catalogue No: abx032258
Price:
US$326.25
(Size: 80 µl)
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This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Research Articles on PTEN (pY176)
| Target | PTEN (pY176) |
| Clonality | Polyclonal |
| Target Modification | Tyr176 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y176 of human PTEN. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P60484 (UniProt, ExPASy) |
| UniProt Secondary AC | B2R904, F2YHV0, O00633, O02679, Q6ICT7 |
| UniProt Entry Name | PTEN_HUMAN |
| Gene Symbol | PTEN |
| KEGG | hsa:5728 |
| String | 9606.ENSP00000361021 |
| Enzyme Commission Number | EC 3.1.3.16 EC 3.1.3.67 EC 3.1.3.48 |
| Molecular Weight | Calculated MW: 47.2 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Xenopus PTEN. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |