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Pancreas Specific Transcription Factor 1a (Ptf1a) Antibody
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Catalogue No: abx031635
Price:
US$290.00
(Size: 80 µl)
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Ptf1a is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. This protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in the Ptf1a gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.
Research Articles on Pancreas Specific Transcription Factor 1a (Ptf1a)
| Target | Pancreas Specific Transcription Factor 1a (Ptf1a) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 12-43 amino acids from the N-terminal region of human Ptf1a. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q7RTS3 (UniProt, ExPASy) |
| UniProt Secondary AC | Q9HC25 |
| UniProt Entry Name | PTF1A_HUMAN |
| Gene Symbol | PTF1A |
| KEGG | hsa:256297 |
| String | 9606.ENSP00000365687 |
| Molecular Weight | Calculated MW: 35 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat PTF1A. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |