Pancreas Specific Transcription Factor 1a (Ptf1a) Antibody

Ptf1a is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. This protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in the Ptf1a gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

Target	Pancreas Specific Transcription Factor 1a (Ptf1a)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 12-43 amino acids from the N-terminal region of human Ptf1a.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q7RTS3 (UniProt, ExPASy)
UniProt Secondary AC	Q9HC25
UniProt Entry Name	PTF1A_HUMAN
Gene Symbol	PTF1A
KEGG	hsa:256297
String	9606.ENSP00000365687
Molecular Weight	Calculated MW: 35 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat PTF1A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Pancreas Specific Transcription Factor 1a (Ptf1a)

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