+44 (0) 1223 755950
+1 832 327 7413
PTK2B (pY402) Antibody
REQUEST MORE INFO
Catalogue No: abx000266
Price:
US$246.50
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
PTK2B (pY402) Antibody is a Rabbit Polyclonal antibody against PTK2B (pY402). This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene.
Research Articles on PTK2B (pY402)
| Target | PTK2B (pY402) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic phosphorylated peptide around Y402 of human PTK2B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q14289 (UniProt, ExPASy) |
| UniProt Secondary AC | D3DST0, Q13475, Q14290, Q16709, Q6PID4 |
| UniProt Entry Name | FAK2_HUMAN |
| Gene Symbol | PTK2B |
| GeneID | 2185 |
| NCBI Accession | NP_004094.3 |
| KEGG | hsa:2185 |
| String | 9606.ENSP00000380638 |
| Molecular Weight | Calculated MW: 116 kDa Observed MW: 116 kDa |
| Buffer | PBS, pH 7.3, containing 0.01% thimerosal, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |