protein Tyrosine Phosphatase 1B (PTP1B) Antibody

PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Target	protein Tyrosine Phosphatase 1B (PTP1B)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 23-53 amino acids from the N-terminal region of human PTP1B.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P18031 (UniProt, ExPASy)
UniProt Secondary AC	Q5TGD8, Q9BQV9, Q9NQQ4
UniProt Entry Name	PTN1_HUMAN
NCBI Accession	NP_001265547.1 NP_002818.1
KEGG	hsa:5770
String	9606.ENSP00000360683
Molecular Weight	Calculated MW: 50 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat PTPN1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on protein Tyrosine Phosphatase 1B (PTP1B)

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