protein Tyrosine Phosphatase 1B (PTP1B) Antibody

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Catalogue No: abx033940
Price: US$326.25
(Size: 80 µl)

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Datasheet SDS
PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.

Target protein Tyrosine Phosphatase 1B (PTP1B)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB
Host Rabbit
Recommended dilutions WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant protein encoding 1-321 AA of human PTP1B.
Isotype IgG
Form Liquid
Purification Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P18031 (UniProt, ExPASy)
UniProt Secondary AC Q5TGD8, Q9BQV9, Q9NQQ4
UniProt Entry Name PTN1_HUMAN
KEGG hsa:5770
String 9606.ENSP00000360683
Molecular Weight Calculated MW: 50 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note This product is for research use only.
Research Articles on protein Tyrosine Phosphatase 1B (PTP1B)


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