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Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) Antibody
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Catalogue No: abx031431
Price:
US$290.00
(Size: 80 µl)
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The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
Research Articles on Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1)
| Target | Tyrosine-Protein Phosphatase Non-Receptor Type 1 (PTPN1) |
| Clonality | Polyclonal |
| Reactivity | Mouse |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 221-249 amino acids from the Central region of human PTPN1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P18031 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5TGD8, Q9BQV9, Q9NQQ4 |
| UniProt Entry Name | PTN1_HUMAN |
| Gene Symbol | PTPN1 |
| KEGG | hsa:5770 |
| String | 9606.ENSP00000360683 |
| Molecular Weight | Calculated MW: 50 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat PTPN1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |