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Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) Antibody
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Catalogue No: abx029236
Price:
US$290.00
(Size: 80 µl)
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STEP (Protein-tyrosine phosphatase striatum-enriched) is a neural-specific protein-tyrosine phosphatase. It is also known as PTPN5 (tyrosine-protein phosphatase, non-receptor type 5). STEP immunoreactive areas are most intense in the regions of the CNS receiving a dopaminergic input (e.g. striatum, basal ganglia). STEP is part of the NMDA receptor (R) complex and inhibits NMDAR single-channel activity and NMDAR-mediated synaptic current. Phosphorylation of STEP, via D1 and PKA activation by dopamine, decreases the activity of STEP by reducing its affinity for substrate.
Research Articles on Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5)
| Target | Protein Tyrosine Phosphatase, Non Receptor Type 5 (PTPN5) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PTPN5. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P54829 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KXG7, B7Z386, B7ZAF5, D3DQY7, Q6P1Z2, Q8N2A1, Q8NDP8 |
| UniProt Entry Name | PTN5_HUMAN |
| KEGG | hsa:84867 |
| String | 9606.ENSP00000351342 |
| Molecular Weight | Calculated MW: 63.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |