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PYD And CARD Domain Containing (PYCARD) Antibody
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Catalogue No: abx001084
Price:
US$203.00
(Size: 20 µl)
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PYCARD Antibody is a Rabbit Polyclonal antibody against PYCARD. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
Research Articles on PYD And CARD Domain Containing (PYCARD)
| Target | PYD And CARD Domain Containing (PYCARD) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 50-195 of human ASC/TMS1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9ULZ3 (UniProt, ExPASy) |
| UniProt Secondary AC | Q96D12, Q9BSZ5, Q9HBD0, Q9NXJ8 |
| UniProt Entry Name | ASC_HUMAN |
| Gene Symbol | PYCARD |
| GeneID | 29108 |
| NCBI Accession | NP_037390.2 |
| String | 9606.ENSP00000247470 |
| Molecular Weight | Calculated MW: 22 kDa Observed MW: 15-19 kDa/20 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |