RAD17 Checkpoint Clamp Loader Component (RAD17) Antibody

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Catalogue No: abx026396
Price: US$326.25
(Size: 80 µl)
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RAD17 Checkpoint Clamp Loader Component (RAD17) Antibody
RAD17 Checkpoint Clamp Loader Component (RAD17) Antibody RAD17 Checkpoint Clamp Loader Component (RAD17) Antibody

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Datasheet SDS
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.

Target RAD17 Checkpoint Clamp Loader Component (RAD17)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, FCM
Host Rabbit
Recommended dilutions WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 218-246 amino acids from the Central region of human RAD17.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC O75943 (UniProt, ExPASy)
UniProt Entry Name RAD17_HUMAN
Gene Symbol RAD17
KEGG hsa:5884
String 9606.ENSP00000426191
Molecular Weight Calculated MW: 77.1 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on RAD17 Checkpoint Clamp Loader Component (RAD17)
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