RAD51 Recombinase (RAD51) Antibody

RAD51 Recombinase (RAD51) Antibody is a Rabbit Polyclonal antibody for the detection of RAD51.

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3.

Target	RAD51 Recombinase (RAD51)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/50 - 1/500. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	RAD51 homolog
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q06609 (UniProt, ExPASy)
UniProt Secondary AC	B0FXP0, B2R8T6, Q6FHX9, Q6ZNA8, Q9BV60
UniProt Entry Name	RAD51_HUMAN
Gene Symbol	RAD51
GeneID	5888
OMIM	114480
HGNC	9817
KEGG	hsa:5888
Ensembl	ENSG00000051180
Molecular Weight	Observed MW: 37 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on RAD51 Recombinase (RAD51)

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