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RAF1 (pY341) Antibody
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Catalogue No: abx032000
Price:
US$326.25
(Size: 80 µl)
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Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Research Articles on RAF1 (pY341)
| Target | RAF1 (pY341) |
| Clonality | Polyclonal |
| Target Modification | Tyr341 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, DB |
| Host | Rabbit |
| Recommended dilutions | DB: 1/500. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y341 of human RAF1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody was eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P04049 (UniProt, ExPASy) |
| UniProt Secondary AC | B0LPH8, B2R5N3, Q15278, Q9UC20 |
| UniProt Entry Name | RAF1_HUMAN |
| KEGG | hsa:5894 |
| String | 9606.ENSP00000251849 |
| Molecular Weight | Calculated MW: 73.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow and Chicken RAF1. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |