+44 (0) 1223 755950
+1 832 327 7413
orders@abbexa.com
Help us improve!
How easy was it for you
to use the website?
to use the website?
How can we improve?
Submit
Sales & Advice:
UK +44 (0) 1223 755950 US +1 832 327 7413 @
Ran GTPase-Activating Protein 1 (RANGAP1) Antibody
REQUEST MORE INFO
Catalogue No: abx027599
Price:
US$326.25
(Size: 80 µl)
Click on the image to see the image legend
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.
Research Articles on Ran GTPase-Activating Protein 1 (RANGAP1)
| Target | Ran GTPase-Activating Protein 1 (RANGAP1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P46060 (UniProt, ExPASy) |
| UniProt Secondary AC | Q96JJ2 |
| UniProt Entry Name | RAGP1_HUMAN |
| Gene Symbol | RANGAP1 |
| GeneID | 5905 |
| OMIM | 602362 |
| NCBI Accession | NP_002874.1 |
| HGNC | 9854 |
| KEGG | hsa:5905 |
| Ensembl | ENSG00000100401 |
| String | 9606.ENSP00000401470 |
| Molecular Weight | Calculated MW: 63.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
