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RAP2A, Member of RAS Oncogene Family (RAP2A) Antibody
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Catalogue No: abx002039
Price:
US$203.00
(Size: 20 µl)
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RAP2A Antibody is a Rabbit Polyclonal antibody against RAP2A. Ras oncogenes encode GTP-binding proteins that are capable of transforming immortalized cells in culture. Two Ras-related human genes, designated RAP1A and RAP1B, encode 95% homologous proteins (namely Rap 1A and Rap 1B) that share a similar C-terminal Cys-Ali-Ali-Xaa sequence with Ras proteins and are ubiquitously expressed in mammalian tissues. The putative effector domain of Ras proteins, whose integrity is required for cell transformation as well as interaction with the putative effector protein GAP, is conserved in both Rap 1 proteins. Rap 1A is thought to interfere with Ras effector function by binding to Ras GAP in a GTP-dependent manner without affecting Rap 1A GTPase activity. Rap 2, another Ras-related protein, shares 60% identity with Rap 1A and exhibits a carboxy terminal CAAX motif and two upstream cysteines similar to those of the H-Ras, K-Ras and N-Ras proteins. In contrast with Rap 1A and Rap 1B, overexpression of Rap 2 does not interfere with the Ras signaling pathway..
Research Articles on RAP2A, Member of RAS Oncogene Family (RAP2A)
| Target | RAP2A, Member of RAS Oncogene Family (RAP2A) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human RAP2A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P10114 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RCJ1, Q5JSC1, Q5JSC2 |
| UniProt Entry Name | RAP2A_HUMAN |
| Gene Symbol | RAP2A |
| GeneID | 5911 |
| NCBI Accession | NP_066361.1 |
| KEGG | hsa:5911 |
| String | 9606.ENSP00000245304 |
| Molecular Weight | Calculated MW: 21 kDa Observed MW: 21 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |