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Raptor (pS863) Antibody
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Catalogue No: abx032010
Price:
US$326.25
(Size: 80 µl)
Orders to United States ship from United States
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Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.
Research Articles on Raptor (pS863)
| Target | Raptor (pS863) |
| Clonality | Polyclonal |
| Target Modification | Ser863 |
| Modification | Phosphorylation |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, DB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500, IHC-P: 1/100, DB: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8N122 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RN36, C6KEF2, F5H7J5, Q8N4V9, Q8TB32, Q9P2P3 |
| UniProt Entry Name | RPTOR_HUMAN |
| NCBI Accession | NP_065812.1 |
| KEGG | hsa:57521 |
| String | 9606.ENSP00000307272 |
| Molecular Weight | Calculated MW: 149 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
