Raptor (pS863) Antibody

Raptor participates in the FRAP1 pathway and associates in a near stoichiometric ratio with FRAP1 to form a nutrient-sensitive complex (NSC). It plays a pivotal role as a scaffold protein in the FRAP1-signaling pathway and this interaction is essential for the catalyzed phosphorylation of EIF4EBP1. It has a positive role in nutrient-stimulated signaling to the downstream effector RPS6KB1. Under nutrient-deprived conditions, raptor serves as a negative regulator of FRAP1 kinase activity. Regulation of the interaction with FRAP1 is a critical mechanism by which cells coordinate the rate of cell growth and maintenance of cell size with different environmental conditions.

Target	Raptor (pS863)
Clonality	Polyclonal
Target Modification	Ser863
Modification	Phosphorylation
Reactivity	Human
Tested Applications	ELISA, WB, IHC, DB
Host	Rabbit
Recommended dilutions	WB: 1/500, IHC-P: 1/100, DB: 1/500. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S863 of human Raptor.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by two-step phosphospecific peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8N122 (UniProt, ExPASy)
UniProt Secondary AC	B2RN36, C6KEF2, F5H7J5, Q8N4V9, Q8TB32, Q9P2P3
UniProt Entry Name	RPTOR_HUMAN
NCBI Accession	NP_065812.1
KEGG	hsa:57521
String	9606.ENSP00000307272
Molecular Weight	Calculated MW: 149 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Raptor (pS863)

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