Retinoic Acid Receptor Alpha (RARA) Antibody

RARA Antibody is a Rabbit Polyclonal antibody against RARA. Retinoids (vitamin A and its active retinoic acid derivatives) are non-steroid hormones that regulate cell prolifeRation, differentiation and apoptosisRetinoic acid receptors (RARalpha, -beta and -gamma) and retinoid X receptors (RXRalpha, -beta and -gamma) are nuclear receptors that function as RAR-RXR heterodimers or RXR homodimersIn response to retinoid binding, these dimers control gene expression by binding to specific retinoic acid response elements, by recruiting cofactors and the transcriptional machinery, and by indirectly regulating chromatin structureFinally, ligand binding and phosphorylation of RARalpha by JNK at Thr181, Ser445 and Ser461 controls the stability of RAR-RXR through the ubiquitin-proteasome pathwayAt least four distinct genetic lesions affect RARalpha and result in acute promyelocytic leukemia (APL)The t(15;17) translocation that results in the PML-RARalpha fusion protein is responsible for more than 99% of APL cases, and the fusion protein inhibits PML-dependent apoptotic pathways in a dominant negative fashionIn addition PML-RARalpha inhibits transcription of retinoic acid target genes by recruiting co-repressors, attenuating myeloid differentiation.

Target	Retinoic Acid Receptor Alpha (RARA)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human RARα.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P10276 (UniProt, ExPASy)
UniProt Secondary AC	B8Y636, P78456, Q13440, Q13441, Q96S41, Q9NQS0
UniProt Entry Name	RARA_HUMAN
Gene Symbol	RARA
GeneID	5914
KEGG	hsa:5914
String	9606.ENSP00000254066
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Retinoic Acid Receptor Alpha (RARA)

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