Ras-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1) Antibody

RASGRF1 Antibody is a Rabbit Polyclonal antibody against RASGRF1. The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Target	Ras-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1)
Clonality	Polyclonal
Reactivity	Mouse
Tested Applications	WB
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human RASGRF1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13972 (UniProt, ExPASy)
UniProt Secondary AC	F8VPA5, H0YKF2, J3KQP9, Q16027
UniProt Entry Name	RGRF1_HUMAN
Gene Symbol	RASGRF1
GeneID	5923
OMIM	606600
NCBI Accession	NP_001139120.1
HGNC	9875
KEGG	hsa:5923
Ensembl	ENSG00000058335
String	9606.ENSP00000405963
Molecular Weight	Calculated MW: 145 kDa Observed MW: 145 kDa
Buffer	PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol.
Concentration	> 0.2 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ras-Specific Guanine Nucleotide-Releasing Factor 1 (RASGRF1)

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