Retinoblastoma Protein 1 (RB1) Antibody

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Catalogue No: abx032759
Price: US$326.25
(Size: 80 µl)
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Retinoblastoma Protein 1 (RB1) Antibody
Retinoblastoma Protein 1 (RB1) Antibody Retinoblastoma Protein 1 (RB1) Antibody Retinoblastoma Protein 1 (RB1) Antibody

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Datasheet SDS
The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer.[1] One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.[2][3] Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

Target Retinoblastoma Protein 1 (RB1)
Clonality Polyclonal
Reactivity Human
Tested Applications ELISA, WB, IHC, IF/ICC
Host Rabbit
Recommended dilutions WB: 1/1000, IHC-P: 1/10 - 1/50, IF/ICC: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen KLH-conjugated synthetic peptide between 586-615 amino acids from human RB1.
Isotype IgG
Form Liquid
Purification Purified through a protein A column, followed by peptide affinity purification.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC P06400 (UniProt, ExPASy)
UniProt Secondary AC A8K5E3, P78499, Q5VW46, Q8IZL4
UniProt Entry Name RB_HUMAN
NCBI Accession NP_000312.2
KEGG hsa:5925
String 9606.ENSP00000267163
Molecular Weight Calculated MW: 106 kDa
Buffer PBS containing 0.09% sodium azide.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Retinoblastoma Protein 1 (RB1)
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