Retinoblastoma-Like Protein 1 (RBL1) Antibody

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.

Target	Retinoblastoma-Like Protein 1 (RBL1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1007-1035 amino acids from the C-terminal region of human RBL1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P28749 (UniProt, ExPASy)
UniProt Secondary AC	A8K2W5, Q4VXA0, Q8N5K6, Q9H1L5, Q9H1M1
UniProt Entry Name	RBL1_HUMAN
Gene Symbol	RBL1
KEGG	hsa:5933
String	9606.ENSP00000362768
Molecular Weight	Calculated MW: 121 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Retinoblastoma-Like Protein 1 (RBL1)

Write a review

Your Name

Your Email Address

PMID

DOI

Your Review

Rating

Continue