Proto-Oncogene C-Rel (REL) Antibody

REL Antibody is a Rabbit Polyclonal antibody against REL. Transcription factors of the nuclear factor κ B (NF-κB)/Rel family play a pivotal role in inflammatory and immune responsesThere are five family members in mammals: RelA, c-Rel, RelB, NF-κB1 (p105/p50), and NF-κB2 (p100/p52)Both p105 and p100 are proteolytically processed by the proteasome to produce p50 and p52, respectivelyRel proteins bind p50 and p52 to form dimeric complexes that bind DNA and regulate transcriptionIn unstimulated cells, NF-κB is sequestered in the cytoplasm by IκB inhibitory proteinsNF-κB-activating agents can induce the phosphorylation of IκB proteins, targeting them for rapid degradation through the ubiquitin-proteasome pathway and releasing NF-κB to enter the nucleus where it regulates gene expressionNIK and IKKα (IKK1) regulate the phosphorylation and processing of NF-κB2 (p100) to produce p52, which translocates to the nucleusThis protein is involved in Transcription.

Target	Proto-Oncogene C-Rel (REL)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Recombinant protein of human REL.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q04864 (UniProt, ExPASy)
UniProt Secondary AC	Q17RU2, Q2PNZ7, Q6LDY0
UniProt Entry Name	REL_HUMAN
Gene Symbol	REL
GeneID	5966
KEGG	hsa:5966
String	9606.ENSP00000295025
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Proto-Oncogene C-Rel (REL)

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