RE1 Silencing Transcription Factor (REST) Antibody

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Target	RE1 Silencing Transcription Factor (REST)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 542-570 amino acids from the Central region of human REST.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13127 (UniProt, ExPASy)
UniProt Secondary AC	A2RUE0, B9EGJ0, Q12956, Q12957, Q13134, Q59ER1, Q8IWI3
UniProt Entry Name	REST_HUMAN
KEGG	hsa:5978
String	9606.ENSP00000311816
Molecular Weight	Calculated MW: 122 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on RE1 Silencing Transcription Factor (REST)

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