Retinal-Specific ATP-Binding Cassette Transporter (ABCA4) Antibody

Retinal-Specific ATP-Binding Cassette Transporter (ABCA4) Antibody is a Rabbit Polyclonal antibody for the detection of ABCA4.

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2.

Target	Retinal-Specific ATP-Binding Cassette Transporter (ABCA4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	ABCA4
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	P78363 (UniProt, ExPASy)
UniProt Secondary AC	O15112, O60438, O60915, Q0QD48, Q4LE31
UniProt Entry Name	ABCA4_HUMAN
Gene Symbol	ABCA4
GeneID	24
OMIM	153800
HGNC	34
KEGG	hsa:24
Ensembl	ENSG00000198691
String	9606.ENSP00000359245
Molecular Weight	Observed MW: 256 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Retinal-Specific ATP-Binding Cassette Transporter (ABCA4)

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