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E3 Ubiquitin-Protein Ligase COP1 (COP1) Antibody
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Catalogue No: abx031297
Price:
US$326.25
(Size: 80 µl)
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E3 Ubiquitin-Protein Ligase COP1 (COP1) mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. They are also involved in JUN ubiquitination and degradation and p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. E3 ubiquitinates p53 independently of MDM2 or RCHY1.
Research Articles on E3 Ubiquitin-Protein Ligase COP1 (COP1)
| Target | E3 Ubiquitin-Protein Ligase COP1 (COP1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 672-701 amino acids from the C-terminal region of Human COP1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q8NHY2 (UniProt, ExPASy) |
| UniProt Secondary AC | E9PKI0, Q504W6, Q6H103, Q9H6L7, X5D9B4 |
| UniProt Entry Name | COP1_HUMAN |
| Gene Symbol | COP1 |
| KEGG | hsa:64326 |
| String | 9606.ENSP00000356641 |
| Molecular Weight | Calculated MW: 80.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse COP1. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |