Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4) Antibody

Ral GDS (Ral guanine nucleotide dissociation stimulator) is a guanine nucleotide exchange factor (GEF) that activates Ral and is implicated in oncogenic Ras-induced cell transformation. RGL4 (ral guanine nucleotide dissociation stimulator-like 4), also known as Rgr, is a 473 amino acid protein that localizes to the cytoplasmic vesicle of cells. Belonging to the GEF family of proteins, RGL4 induces phosphorylation of ERKs, p38 and JNK kinases, and it increases the levels of GTP bound forms of Ral and Ras. Ras activation is crucial for the transforming activity of RGL4. Due to its similarity to Ral GDS, RGL4 may be implicated in carcinogenesis.

Target	Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 98-125 amino acids from the N-terminal region of human RGL4.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8IZJ4 (UniProt, ExPASy)
UniProt Secondary AC	Q495L8
UniProt Entry Name	RGDSR_HUMAN
Gene Symbol	RGL4
KEGG	hsa:266747
String	9606.ENSP00000290691
Molecular Weight	Calculated MW: 52.3 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ral Guanine Nucleotide Dissociation Stimulator-Like 4 (RGL4)

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