Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1) Antibody

Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1) Antibody is a Rabbit Polyclonal antibody for the detection of ARHGEF1.

Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.

Target	Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1)
Clonality	Polyclonal
Reactivity	Human, Rat
Tested Applications	ELISA, IHC
Host	Rabbit
Recommended dilutions	IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Rho guanine nucleotide exchange factor(GEF) 1
Isotype	IgG
Form	Liquid
Purity	≥ 95% (SDS-PAGE)
Purification	Purified by immunogen affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Validity	12 months.
UniProt Primary AC	Q92888 (UniProt, ExPASy)
UniProt Secondary AC	O00513, Q6NX52, Q8N4J4, Q96BF4, Q96F17, Q9BSB1
UniProt Entry Name	ARHG1_HUMAN
Gene Symbol	ARHGEF1
GeneID	9138
OMIM	601855
HGNC	681
KEGG	hsa:9138
Ensembl	ENSG00000076928
String	9606.ENSP00000337261
Molecular Weight	Observed MW: 102-110 kDa
Buffer	PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Concentration	2 mg/ml
Availability	Shipped within 5-12 working days.
Note	This product is for research use only.

Research Articles on Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1)

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