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Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1) Antibody
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Catalogue No: abx217576
Price:
US$406.00
(Size: 100 µg)
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Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1) Antibody is a Rabbit Polyclonal antibody for the detection of ARHGEF1. Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
Research Articles on Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1)
| Target | Rho Guanine Nucleotide Exchange Factor 1 (ARHGEF1) |
| Clonality | Polyclonal |
| Reactivity | Human, Rat |
| Tested Applications | ELISA, IHC |
| Host | Rabbit |
| Recommended dilutions | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Rho guanine nucleotide exchange factor(GEF) 1 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q92888 (UniProt, ExPASy) |
| UniProt Secondary AC | O00513, Q6NX52, Q8N4J4, Q96BF4, Q96F17, Q9BSB1 |
| UniProt Entry Name | ARHG1_HUMAN |
| Gene Symbol | ARHGEF1 |
| GeneID | 9138 |
| OMIM | 601855 |
| HGNC | 681 |
| KEGG | hsa:9138 |
| Ensembl | ENSG00000076928 |
| String | 9606.ENSP00000337261 |
| Molecular Weight | Observed MW: 102-110 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |