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Rapamycin-Insensitive Companion of mTOR (RICTOR) Antibody
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Catalogue No: abx015977
Price:
US$420.50
(Size: 100 µl)
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Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size.The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals.mTOR is a large protein kinase with two different complexes.One complex contains mTOR, G beta L and raptor, which is a target of rapamycin.The other complex, insensitive to rapamycin, includes mTOR, G beta L, Sin1 and rictor.The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro.This phosphorylation is essential for full Akt/PKB activation.Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes.This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR.
Research Articles on Rapamycin-Insensitive Companion of mTOR (RICTOR)
| Target | Rapamycin-Insensitive Companion of mTOR (RICTOR) |
| Clonality | Monoclonal |
| Reactivity | Human, Monkey, Mouse |
| Tested Applications | ELISA |
| Host | Mouse |
| Recommended dilutions | ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Purified recombinant fragment of human RICTOR expressed in E. coli. |
| Isotype | IgG1 |
| Form | Liquid |
| Purification | Unpurified ascites. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q6R327 (UniProt, ExPASy) |
| UniProt Secondary AC | B2RNX0, B7ZMF7, Q68DT5, Q86UB7, Q8N3A0, Q8NCM6 |
| UniProt Entry Name | RICTR_HUMAN |
| Gene Symbol | RICTOR |
| GeneID | 253260 |
| OMIM | 609022 |
| HGNC | 28611 |
| KEGG | hsa:253260 |
| Ensembl | ENSG00000164327 |
| String | 9606.ENSP00000296782 |
| Molecular Weight | 192 kDa |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Concentration | Not determined. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |