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Ring Finger Protein 34 (RNF34) Antibody
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Catalogue No: abx240012
Price:
US$406.00
(Size: 100 µg)
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Ring Finger Protein 34 (RNF34) Antibody is a Rabbit Polyclonal antibody for the detection of RNF34. E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).
Research Articles on Ring Finger Protein 34 (RNF34)
| Target | Ring Finger Protein 34 (RNF34) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | ring finger protein 34 |
| Isotype | IgG |
| Form | Liquid |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Validity | 12 months. |
| UniProt Primary AC | Q969K3 (UniProt, ExPASy) |
| UniProt Secondary AC | B7Z933, Q8NG47, Q9H6W8 |
| UniProt Entry Name | RNF34_HUMAN |
| Gene Symbol | RNF34 |
| GeneID | 80196 |
| OMIM | 608299 |
| NCBI Accession | NP_001243787.1 NM_001256858.1 NP_079402.2 NM_025126.3 |
| KEGG | hsa:80196 |
| String | 9606.ENSP00000376258 |
| Molecular Weight | Observed MW: 41 kDa |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Concentration | 2 mg/ml |
| Availability | Shipped within 5-12 working days. |
| Note | This product is for research use only. |