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Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Antibody
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Catalogue No: abx027672
Price:
US$326.25
(Size: 80 µl)
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Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.
Research Articles on Receptor Interacting Serine Threonine Kinase 1 (RIPK1)
| Target | Receptor Interacting Serine Threonine Kinase 1 (RIPK1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 152-180 amino acids from the N-terminal region of human RIPK1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q13546 (UniProt, ExPASy) |
| UniProt Secondary AC | A0AV89, B2RAG1, B4E3F9, Q13180, Q59H33 |
| UniProt Entry Name | RIPK1_HUMAN |
| KEGG | hsa:8737 |
| String | 9606.ENSP00000259808 |
| Molecular Weight | Calculated MW: 75.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |