Receptor Interacting Serine Threonine Kinase 1 (RIPK1) Antibody

Essential adapter molecule for the activation of NF-kappa-B. Following different upstream signals (binding of inflammatory cytokines, stimulation of pathogen recognition receptors, or DNA damage), particular RIPK1-containing complexes are formed, initiating a limited number of cellular responses. Upon TNFA stimulation RIPK1 is recruited to a TRADD-TRAF complex initiated by TNFR1 trimerization. There, it is ubiquitinated via 'Lys-63'-link chains, inducing its association with the IKK complex, and its activation through NEMO binding of polyubiquitin chains.

Target	Receptor Interacting Serine Threonine Kinase 1 (RIPK1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 152-180 amino acids from the N-terminal region of human RIPK1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13546 (UniProt, ExPASy)
UniProt Secondary AC	A0AV89, B2RAG1, B4E3F9, Q13180, Q59H33
UniProt Entry Name	RIPK1_HUMAN
KEGG	hsa:8737
String	9606.ENSP00000259808
Molecular Weight	Calculated MW: 75.9 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Receptor Interacting Serine Threonine Kinase 1 (RIPK1)

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