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Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A) Antibody
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Catalogue No: abx027899
Price:
US$326.25
(Size: 80 µl)
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The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.
Research Articles on Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A)
| Target | Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9NV58 (UniProt, ExPASy) |
| UniProt Secondary AC | A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1 |
| UniProt Entry Name | RN19A_HUMAN |
| Gene Symbol | RNF19A |
| String | 9606.ENSP00000428968 |
| Molecular Weight | Calculated MW: 90.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse and Pig RNF19A. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |