Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A) Antibody

The protein encoded this gene contains two RING-finger motifs and an IBR (in between RING fingers) motif. This protein is an E3 ubiquintin ligase that is localized in Lewy bodies (LBs), a characteristic neuronal inclusion in Parkinson's disease (PD) brains. This protein interacts with UBE2L3/UBCH7 and UBE2E2/UBCH8, but not other ubiquitin-conjugating enzymes. This protein is found to bind and ubiquitylate synphilin 1 (SNCAIP), which is a interacting protein of alpha synuclein in neurons, and a major component of LB. Alternatively spliced transcript variants encoding the same protein have been reported.

Target	Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 384-413 amino acids from the Central region of human RNF19A.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q9NV58 (UniProt, ExPASy)
UniProt Secondary AC	A3KCU9, Q52LG1, Q9H5H9, Q9H8M8, Q9UFG0, Q9UFX6, Q9Y4Y1
UniProt Entry Name	RN19A_HUMAN
Gene Symbol	RNF19A
String	9606.ENSP00000428968
Molecular Weight	Calculated MW: 90.7 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Pig RNF19A.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ring Finger Protein 19A, RBR E3 Ubiquitin Protein Ligase (RNF19A)

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