Rho-Associated Protein Kinase 1 (ROCK1) Antibody

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Target	Rho-Associated Protein Kinase 1 (ROCK1)
Clonality	Monoclonal
Reactivity	Human
Tested Applications	ELISA
Host	Mouse
Recommended dilutions	ELISA: 1/10000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	Purified recombinant fragment of human ROCK1 expressed in E. coli.
Isotype	IgG1
Form	Liquid
Purification	Purified from ascites by Protein G chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q13464 (UniProt, ExPASy)
UniProt Secondary AC	B0YJ91, Q2KHM4, Q59GZ4
UniProt Entry Name	ROCK1_HUMAN
Gene Symbol	ROCK1
GeneID	6093
OMIM	601702
HGNC	10251
KEGG	hsa:6093
Ensembl	ENSG00000067900
String	9606.ENSP00000382697
Molecular Weight	158 kDa
Buffer	PBS, containing 0.05% sodium azide.
Concentration	1 mg/ml
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Rho-Associated Protein Kinase 1 (ROCK1)

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