Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody

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Catalogue No: abx011486
Price: US$427.75
(Size: 100 µl)

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Western blot analysis using ROR1 antibody against extracellular domain of human ROR1 (aa30-423).
Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1) Antibody

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Datasheet SDS
ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.

Target Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)
Clonality Monoclonal
Reactivity Human
Tested Applications ELISA, IF/ICC
Host Mouse
Recommended dilutions ELISA: 1/10000, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation Unconjugated
Immunogen Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells.
Isotype IgG1
Form Liquid
Purification Unpurified ascites.
Storage Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC Q01973 (UniProt, ExPASy)
UniProt Secondary AC Q5VVX6, Q66K77, Q92776
UniProt Entry Name ROR1_HUMAN
Gene Symbol ROR1
GeneID 4919
OMIM 602336
HGNC 10256
KEGG hsa:4919
Ensembl ENSG00000185483
String 9606.ENSP00000360120
Molecular Weight 101 kDa
Buffer Ascitic fluid containing 0.03% sodium azide.
Concentration Not determined.
Availability Shipped within 5-10 working days.
Note THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
Research Articles on Receptor Tyrosine Kinase Like Orphan Receptor 1 (ROR1)
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