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Replication Protein A 70 kDa DNA-Binding Subunit (RPA1) Antibody
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Catalogue No: abx028041
Price:
US$326.25
(Size: 80 µl)
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RPA1 plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.
Research Articles on Replication Protein A 70 kDa DNA-Binding Subunit (RPA1)
| Target | Replication Protein A 70 kDa DNA-Binding Subunit (RPA1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 531-559 amino acids from the C-terminal region of human RPA1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P27694 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K0Y9, Q59ES9 |
| UniProt Entry Name | RFA1_HUMAN |
| Gene Symbol | RPA1 |
| KEGG | hsa:6117 |
| String | 9606.ENSP00000254719 |
| Molecular Weight | Calculated MW: 68.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |