Replication Protein A 70 kDa DNA-Binding Subunit (RPA1) Antibody

RPA1 plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing. Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.

Target	Replication Protein A 70 kDa DNA-Binding Subunit (RPA1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 531-559 amino acids from the C-terminal region of human RPA1.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P27694 (UniProt, ExPASy)
UniProt Secondary AC	A8K0Y9, Q59ES9
UniProt Entry Name	RFA1_HUMAN
Gene Symbol	RPA1
KEGG	hsa:6117
String	9606.ENSP00000254719
Molecular Weight	Calculated MW: 68.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Replication Protein A 70 kDa DNA-Binding Subunit (RPA1)

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