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DNA-Directed RNA Polymerase III Subunit RPC8 (RPC8) Antibody
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Catalogue No: abx032349
Price:
US$326.25
(Size: 80 µl)
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RPC8 is DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. It is plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. It is acting as nuclear and cytosolic DNA sensor involved in innate immune response. It can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway.
Research Articles on DNA-Directed RNA Polymerase III Subunit RPC8 (RPC8)
| Target | DNA-Directed RNA Polymerase III Subunit RPC8 (RPC8) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, FCM: 1/10 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 5-33 amino acids from the N-terminal region of human RPC8. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9Y535 (UniProt, ExPASy) |
| UniProt Secondary AC | B0QYH9, Q5M7Y8, Q96AE3, Q9BY95 |
| UniProt Entry Name | RPC8_HUMAN |
| Gene Symbol | POLR3H |
| String | 9606.ENSP00000347345 |
| Molecular Weight | Calculated MW: 22.9 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |