Ribosomal Protein L22 (RPL22) Antibody

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L22E family of ribosomal proteins. Its initiating methionine residue is post-translationally removed. The protein can bind specifically to Epstein-Barr virus-encoded RNAs (EBERs) 1 and 2. The mouse protein has been shown to be capable of binding to heparin. Transcript variants utilizing alternative polyA signals exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. It was previously thought that this gene mapped to 3q26 and that it was fused to the acute myeloid leukemia 1 (AML1) gene located at 21q22 in some therapy-related myelodysplastic syndrome patients with 3;21 translocations; however, these fusions actually involve a ribosomal protein L22 pseudogene located at 3q26, and this gene actually maps to 1p36.3-p36.2.

Target	Ribosomal Protein L22 (RPL22)
Clonality	Polyclonal
Reactivity	Human, Mouse
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 92-121 amino acids from the C-terminal region of human RPL22.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P35268 (UniProt, ExPASy)
UniProt Secondary AC	B2R495, Q6IBD1
UniProt Entry Name	RL22_HUMAN
Gene Symbol	RPL22
KEGG	hsa:6146
String	9606.ENSP00000346088
Molecular Weight	Calculated MW: 14.8 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Rat, Pig, Chicken, Monkey and Xenopus RPL22.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Ribosomal Protein L22 (RPL22)

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