Runt Related Transcription Factor (RUNX1) Antibody

RUNX1 Antibody is a Rabbit Polyclonal antibody against RUNX1. AML1 (also known as Runx1, CBFA2, and PEBP2αB) is a member of the core binding factor (CBF) family of transcription factorsIt is required for normal development of all hematopoietic lineagesAML1 forms a heterodimeric DNA binding complex with its partner protein CBFβ and regulates the expression of cellular genes by binding to promoter and enhancer elementsAML1 is commonly translocated in hematopoietic cancers: chromosomal translocations include t(8;21) AML1-ETO, t(12;21) TEL-AML, and t(8;21) AML-M2Phosphorylation of AML1 on several potential serine and threonine sites, including Ser249, is thought to occur in an Erk-dependent manner.

Target	Runt Related Transcription Factor (RUNX1)
Clonality	Polyclonal
Reactivity	Human, Mouse, Rat
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	A synthetic peptide of human RUNX1.
Isotype	IgG
Form	Liquid
Purification	Purified by affinity chromatography.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q01196 (UniProt, ExPASy)
UniProt Entry Name	RUNX1_HUMAN
Gene Symbol	RUNX1
GeneID	861
KEGG	hsa:861
String	9606.ENSP00000300305
Buffer	PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Runt Related Transcription Factor (RUNX1)

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