+44 (0) 1223 755950
+1 832 327 7413
Ryanodine Receptor 2 (RYR2) Antibody
REQUEST MORE INFO
Catalogue No: abx000677
Price:
US$203.00
(Size: 20 µl)
Reviews: 
(0 Publications and Reviews)
(0 Publications and Reviews)
Click on the image to see the image legend
RYR2 Antibody is a Rabbit Polyclonal antibody against RYR2. RYR2 belongs to the ryanodine receptor family. RYR2 provides communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Defects in RYR2 are the cause of familial arrhythmogenic right ventricular dysplasia type 2 (ARVD2) which known as arrhythmogenic right ventricular cardiomyopathy 2 (ARVC2). Defects in RYR2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) which known as stress-induced polymorphic ventricular tachycardia (VTSIP). This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008].
Research Articles on Ryanodine Receptor 2 (RYR2)
| Target | Ryanodine Receptor 2 (RYR2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/100 - 1/500, IF/ICC: 1/50 - 1/200. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 4868-4967 of human RYR2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92736 (UniProt, ExPASy) |
| UniProt Secondary AC | Q15411, Q546N8, Q5T3P2 |
| UniProt Entry Name | RYR2_HUMAN |
| Gene Symbol | RYR2 |
| GeneID | 6262 |
| NCBI Accession | NP_001026.2 |
| KEGG | hsa:6262 |
| String | 9606.ENSP00000355533 |
| Molecular Weight | Calculated MW: 565 kDa Observed MW: 564 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 0.59 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |