Synapses of Amphids Defective Homolog 1 (SAD1) Antibody

BRSK1 may be involved as a checkpoint kinase in the regulation of G2/M arrest in response to UV or methyl methane sulfonate (MMS) induced, but not IR-induced, DNA damage. This protein phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. BRSK1 is partitioned between cytoplasmic and nuclear locations in the absence of DNA damage, but translocates to the nucleus in response to Uv or MMS-induced DNA damage. BRSK1 shares significant homology with the fission yeast Cdr2, a mitosis-regulatory kinase, and Caenorhabditis elegans SAD1, a neuronal cell polarity regulator. The BRSK1 transcript is expressed ubiquitously with the highest levels of expression in brain and testis.

Target	Synapses of Amphids Defective Homolog 1 (SAD1)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 108-139 amino acids from the N-terminal region of human SAD1 (BRSK1).
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q8TDC3 (UniProt, ExPASy)
UniProt Secondary AC	F1DG44, Q5J5B5, Q8NDD0, Q8NDR4, Q8TDC2, Q96AV4, Q96JL4
UniProt Entry Name	BRSK1_HUMAN
KEGG	hsa:84446
String	9606.ENSP00000310649
Molecular Weight	Calculated MW: 85.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Rat BRSK1.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Synapses of Amphids Defective Homolog 1 (SAD1)

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