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Sodium Voltage-Gated Channel Beta Subunit 1 (SCN1B) Antibody
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Catalogue No: abx025818
Price:
US$326.25
(Size: 80 µl)
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Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. SCN1B encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene.
Research Articles on Sodium Voltage-Gated Channel Beta Subunit 1 (SCN1B)
| Target | Sodium Voltage-Gated Channel Beta Subunit 1 (SCN1B) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse |
| Tested Applications | ELISA, WB, IHC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q07699 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5TZZ4, Q6TN97 |
| UniProt Entry Name | SCN1B_HUMAN |
| NCBI Accession | NP_001028.1 NP_950238.1 |
| KEGG | hsa:6324 |
| String | 9606.ENSP00000396915 |
| Molecular Weight | Calculated MW: 24.7 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Rat, Cow and Rabbit SCN1B. |
| Availability | Shipped within 5-10 working days. |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |