Succinate Dehydrogenase Complex Subunit B (SDHB) Antibody

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

Target	Succinate Dehydrogenase Complex Subunit B (SDHB)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 205-234 amino acids from the C-terminal region of human SDHB.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P21912 (UniProt, ExPASy)
UniProt Secondary AC	B2R545, Q0QEY7, Q9NQ12
UniProt Entry Name	SDHB_HUMAN
Gene Symbol	SDHB
KEGG	hsa:6390
String	9606.ENSP00000364649
Molecular Weight	Calculated MW: 31.6 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Cow and Pig SDHB.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Succinate Dehydrogenase Complex Subunit B (SDHB)

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