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Neuroserpin (SERPINI1) Antibody
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Catalogue No: abx025697
Price:
US$326.25
(Size: 80 µl)
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This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Research Articles on Neuroserpin (SERPINI1)
| Target | Neuroserpin (SERPINI1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100, IF/ICC: 1/10 - 1/50, FCM: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human SERPINI1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q99574 (UniProt, ExPASy) |
| UniProt Secondary AC | A8K217, D3DNP1, Q6AHZ4 |
| UniProt Entry Name | NEUS_HUMAN |
| Gene Symbol | SERPINI1 |
| KEGG | hsa:5274 |
| String | 9606.ENSP00000295777 |
| Molecular Weight | Calculated MW: 46.4 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |