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SET Domain Containing Protein 2 (SETD2) Antibody
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Catalogue No: abx002294
Price:
US$203.00
(Size: 20 µl)
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SETD2 Antibody is a Rabbit Polyclonal antibody against SETD2. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.
Research Articles on SET Domain Containing Protein 2 (SETD2)
| Target | SET Domain Containing Protein 2 (SETD2) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IF/ICC: 1/50 - 1/200, IP: 0.5-4 µg/400-600 µg whole cell extracts. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 2475-2564 of human SETD2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q9BYW2 (UniProt, ExPASy) |
| UniProt Entry Name | SETD2_HUMAN |
| Gene Symbol | SETD2 |
| GeneID | 29072 |
| NCBI Accession | NP_054878.5 |
| String | 9606.ENSP00000386759 |
| Molecular Weight | Calculated MW: 288 kDa Observed MW: 288 kDa |
| Buffer | PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol. |
| Concentration | 1.23 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |