Splicing Factor 3B Subunit 3 (SF3B3) Antibody

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF (II) 31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF (II) containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.

Target	Splicing Factor 3B Subunit 3 (SF3B3)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB
Host	Rabbit
Recommended dilutions	WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 1046-1074 amino acids from the C-terminal region of human SF3B3.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein A column, followed by peptide affinity purification.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	Q15393 (UniProt, ExPASy)
UniProt Secondary AC	Q6NTI8, Q96GC0, Q9BPY2, Q9UFX7, Q9UJ29
UniProt Entry Name	SF3B3_HUMAN
KEGG	hsa:23450
String	9606.ENSP00000305790
Molecular Weight	Calculated MW: 136 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse and Cow SF3B3.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on Splicing Factor 3B Subunit 3 (SF3B3)

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