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Splicing Factor Proline And Glutamine Rich (SFPQ) Antibody
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Catalogue No: abx000914
Price:
US$203.00
(Size: 20 µl)
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SFPQ Antibody is a Rabbit Polyclonal antibody against SFPQ. SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. Catalog# 15585-1-AP is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.
Research Articles on Splicing Factor Proline And Glutamine Rich (SFPQ)
| Target | Splicing Factor Proline And Glutamine Rich (SFPQ) |
| Clonality | Polyclonal |
| Reactivity | Human, Mouse, Rat |
| Tested Applications | WB, IHC, IF/ICC, IP |
| Host | Rabbit |
| Recommended dilutions | WB: 1/500 - 1/1000, IHC-P: 1/50 - 1/200, IF/ICC: 1/50 - 1/100, IP: 0.5-4 µg/200-400 µg whole cell extracts. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 578-707 of human SFPQ. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified by affinity chromatography. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | P23246 (UniProt, ExPASy) |
| UniProt Secondary AC | P30808, Q5SZ71 |
| UniProt Entry Name | SFPQ_HUMAN |
| Gene Symbol | SFPQ |
| GeneID | 6421 |
| NCBI Accession | NP_005057.1 |
| KEGG | hsa:6421 |
| String | 9606.ENSP00000349748 |
| Molecular Weight | Calculated MW: 76 kDa Observed MW: 115 kDa |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Concentration | > 0.2 mg/ml |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |