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Splicing Factor, Arginine/serine-Rich 2 (SFRS2) Antibody
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Catalogue No: abx031712
Price:
US$326.25
(Size: 80 µl)
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SFRS2 is necessary for the splicing of pre-mRNA. The protein is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5' and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. And it interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5' and 3'-splice site binding components, U1 snRNP and U2AF. It binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3' and can bind to beta-globin mRNA and commit it to the splicing pathway.
Research Articles on Splicing Factor, Arginine/serine-Rich 2 (SFRS2)
| Target | Splicing Factor, Arginine/serine-Rich 2 (SFRS2) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 9-39 amino acids from the N-terminal region of human SFRS2. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q01130 (UniProt, ExPASy) |
| UniProt Secondary AC | B3KWD5, B4DN89, H0YG49 |
| UniProt Entry Name | SRSF2_HUMAN |
| KEGG | hsa:6427 |
| String | 9606.ENSP00000376276 |
| Molecular Weight | Calculated MW: 25.5 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Specificity | Predicted to react with Mouse, Rat, Cow, Pig and Chicken SRSF2. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |